Description: Arylamine N-acetyltransferases In Health And Disease: From Pharmacogenetics To Drug Discovery And DiagnosticsAuthor(s): Nicola Laurieri, Edith Sim Format: Hardback Publisher: World Scientific Publishing Co Pte Ltd, Singapore Imprint: World Scientific Publishing Co Pte Ltd ISBN-13: 9789813232006, 978-9813232006 Synopsis This book is a fascinating overview of one of the first pharmacogenetic traits to be identified as responsible for genetic variation in response to drugs ? the understanding of the arylamine N-acetyltransferases (NATs) is linked to many important therapeutic areas, particularly tuberculosis and also cancer. NATs have been important in the metabolism of established anti-tubercular drugs and also in carcinogenesis and susceptibility to bladder cancer. The reach of these enzymes spans pharmacology and therapeutics as well as toxicology and pharmacogenetics. The NAT genes are encoded in a highly polymorphic region of the human genome which has been explored for fine mapping in molecular anthropological [url] book takes a wide ranging approach covering all aspects of the arylamine N-acetyltransferases from genetics to the chemistry and structural biology of the enzymes in the organisms in which they are found, from humans to bacteria and fungi where they appear to have distinct roles. The coverage is by experts in the field from across the globe.
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Book Title: Arylamine N-acetyltransferases In Health And Disease: From Pha...
Publisher: World Industries Scientific Publishing Co Pte LTD
Publication Year: 2018
Subject: Medicine, Chemistry
Number of Pages: 456 Pages
Language: English
Publication Name: Arylamine N-acetyltransferases In Health And Disease: From Pharmacogenetics To Drug Discovery And Diagnostics
Type: Textbook
Author: Edith Sim, Nicola Laurieri
Format: Hardcover
